apalutamide will minimize the extent or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medications that happen to be CYP3A4 substrates may result in decreased exposure to those prescription drugs.

The regulation of modafinil as a doping agent is controversial while in the sporting world, with substantial-profile conditions attracting push protection considering that numerous prominent American athletes analyzed positive for that substance. Some athletes who applied modafinil protested which the drug wasn't to the prohibited listing at enough time of their offenses.

iloperidone improves levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Iloperidone is often a time-dependent CYP3A inhibitor and may cause amplified plasma amounts of medicines predominantly removed by CYP3A4.

This medicine may perhaps impair your contemplating or reactions. Be cautious should you drive or do nearly anything that needs you to definitely be notify.

Teens and children more youthful than 17 years of age—Use and dose has to be determined by your medical doctor.

If you think There have been an overdose, connect with your poison Handle Heart or get clinical care straight away. Be able to explain to or clearly show what was taken, the amount, and when it took place.

Shift-get the job done snooze disorder is usually a circadian rhythm disturbance that usually occurs in Individuals more info who have to work during a time when they'd usually be sleeping. It is especially characterized by extreme sleepiness in the course of Operating hours, and insomnia in the course of sleeping several hours.

Start Manage capsules might not operate effectively if you are using this medication. Check with your health care provider about using an additional method of birth Handle.

Even though there is some respectable evidence that it may be useful, the readily available exploration is not but strong ample to have met the FDA’s criteria for professional medical acceptance, and so this stays an “unofficial” utilization of modafinil.

Furthermore, Cephalon entered agreements with several generic drug suppliers to delay the sale of generic modafinil inside the US.

Signs of substantial hypertension like very bad headache or dizziness, passing out, or improve in vision.

It's not necessarily recognized whether this medication will harm an unborn child. Convey to your medical professional If you're pregnant or system to be Expecting.

enasidenib will improve the stage or influence of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Monitor. Enasidenib (a weak CYP2C19 inhibitor) may perhaps boost systemic publicity of sensitive CYP2C19 substrates. Monitor and adjust dose of substrate as clinically indicated.

Modafinil is investigated to find out irrespective of whether it'd strengthen abstinence in individuals with copyright addiction.[258]